Accelerating Biosafety Testing with the MilliporeSigma BioReliance® Blazar™ Platform: Reducing Release from Weeks to Days

Accelerating Biosafety Testing with the MilliporeSigma BioReliance® Blazar™ Platform: Reducing Release from Weeks to Days

07/16/2020, 4:15 PM - 5:00 PM

Stage 4, Booth 2276, Exhibit Hall
Language:
English
The detection of viral contaminants in biologic therapies is almost entirely dependent on cultivation based methods which take several weeks. Industry groups have identified that viral detection is the bottleneck in releasing batches. Indeed, ADVTIG is actively investigating the use of faster alternative methods such as NGS, however sensitivity and speed remain an issue. We have developed a novel platform which can address these issues whilst maintaining the ability to detect a broad range of known and unknown viruses. The BioReliance® Blazar™ platform uses a degenerate PCR approach to detect pathogens rapidly at high sensitivity and specificity. This platform is already substituting in vivo viral screening and is now being expanded to cover viral screening of CHO based antibody lot release testing. Reducing this bottleneck from several weeks down to days can allow manufacturers to gain efficiencies, and ultimately adopt continuous and intensified processes.

Contributors

  • Afshin Sohrabi

    Speaker

    Senior Development Scientist

    Millipore Sigma

    Dr Afshin Sohrabi is the Head of Development for Rapid Methods at MilliporeSigma BioReliance® services. He is leading a highly technical team...

Objective

  1. Objective 1. Give an overview of the BioReliance® Blazar™ platform 2. Show data demonstrating sensitivity, specificity and performance of the platform. 3. Illustrate the benefits of this platform to reduce the need for lengthy in vivo and in vitro based virus screening

Type of Session

  1. Type of Session
    Session

Categories

  1. Track
    Processing/Manufacturing

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