Impact of Tank Cone Bottom Interior Angle on Agitator Design, Lowest Mixable Volume, and Process Results

Impact of Tank Cone Bottom Interior Angle on Agitator Design, Lowest Mixable Volume, and Process Results

04/17/2018, 11:30 AM - 12:15 PM

Technical Conference Stage 3, Booth 1376, Exhibit Hall

Language:
English

The pharmaceutical and biotechnology industries often utilize vessels with cone bottoms. Cone bottoms are selected to enhance product recovery and improve cleanability compared to dish bottoms. Steeper cone walls produced by smaller interior angles increase the aforementioned characteristics while also reducing the volume per liquid height ratio along the cone. Reduction of the volume per liquid height ratio is desirable because it is perceived to minimize the unmixed heel that occurs during product draw off. However, steep cone walls with small interior angles affect agitator design and may compromise process results. The ramifications of three cone bottom interior angles (60°, 90°, and 120°) on agitator design, mixable volume, and process results will be discussed with respect to a 500 L batch in a 36 in diameter vessel. Guidelines for impeller diameter and placement will be provided and determine the lowest mixable volume. Impeller placement combined with total vessel height will determine shaft length and inform on the mechanical design of the agitator. The effect of impeller diameter and placement on potential process results will be reviewed utilizing computational fluid dynamic (CFD) simulations. The concepts regarding cone bottom interior angle from the 500 L batch example will be generalized for application at any scale. The impact of 60°, 90°, and 120° cone bottom interior angles on agitator design and process results will be discussed utilizing tank layout drawings, characteristic mixer calculations, and CFD simulations to provide general recommendations for industry implementation.

Contributors

  • Aaron Strand

    Speaker

    Research Engineer

    SPXFlow Lightnin

    Aaron Strand is a Research Engineer with SPX Flow Lightnin. He earned a BS in Chemical Engineering from the University of Wisconsin - Madison and is...

Type of Session

  1. Type of Session
    Session

Learning Objectives

  1. Learning Objectives 1. Recognize the affects of cone bottom interior angle selection on vessel layout and agitator design. 2. Identify process implications of vessel layout and agitator design. 3. Incorporate cone bottom interior angle selection concepts in system design.

Categories

  1. Track
    Manufacturing Efficiencies & Improvements

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