Single Use Applications in Continuous Biopharmaceutical Processing

Single Use Applications in Continuous Biopharmaceutical Processing

04/18/2018, 3:15 PM - 4:00 PM

Technical Conference Stage 2, Booth 1177, Exhibit Hall

Language:
English

Implemented and developing trends in the biopharmaceutical manufacturing industry respectively include single use technology (SUT) and continuous bioprocessing. The overlap of these technologies has a significant impact on facility design and operation. A model process based upon a typical monoclonal antibody process was developed and evaluated. Production unit operations considered bioreactors, biomass removal and clarification, chromatography, ultrafiltration and cartridge filtration. Major impacts to the supporting systems media preparation and hold, and buffer preparation and hold are highlighted. This presentation presents options based upon currently available SUT systems for conversion of traditional batch bioprocessing to continuous bioprocessing. Potential SUT options were evaluated, focusing on operational scale, facility impacts, automation and operational considerations. Opportunities for bridging technologies will also be presented.

Contributors

  • Craig Sandstrom

    Speaker

    Director Process Engineering

    Fluor

    Craig has 25 years of experience in biopharmaceutical process development and design. He has worked on design projects including feasibility studies,...

  • Alli Klein

    Speaker

    Process Engineer

    Fluor

    Alli is a process engineer with experience in the design of biopharmaceutical facilities, as well as the design of sulfur recovery and gasification...

Type of Session

  1. Type of Session
    Session

Learning Objectives

  1. Learning Objectives 1. Understand process impacts on process design resulting from continuous manufacturing 2. Understand strategies to implement single use technology in continuous biopharmaceutical manufacturing 3. Identify industry opportunities for technology development to further implement continuous manufacturing

Categories

  1. Track
    Continuous Manufacturing

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