Impacts on Facilities and Process Support from Continuous Processing

Impacts on Facilities and Process Support from Continuous Processing

03/22/2017, 3:15 PM - 4:00 PM

Meeting Room 2

Language:
English

The biopharmaceutical manufacturing industry has expressed increased interest in continuous processing. To a large extent, the development of continuous processes has focused on bioreactors, chromatography and tangential flow filtration systems. In almost all cases, these have significantly reduced the size and associated foot-print of these unit operations. The larger impact on facility support systems, such as water-for-injection, buffer preparation and supply, media preparation and supply, warehouse & dispensing, clean-in-place systems, black utility systems and process waste systems has not been extensively investigated. This presentation compares and contrasts the facility support requirements for: batch vs. perfusion bioreactor operation; batch vs. simulated moving bed chromatography, and batch vs. continuous tangential flow filtration. This evaluation looks at the impact on equipment costs, automation level, and facility design and size.

Contributors

  • Melinda Covert

    Speaker

    Process Engineer

    Fluor

  • Craig Sandstrom

    Speaker

    Director Process Engineering

    Fluor

Documents

Type of Session

  1. Type of Session
    Session

Learning Objectives

  1. Learning Objectives 1. Understand the differences in process support system requirements resulting from a change from batch to continuous bioprocessing 2. Understand the differences in facility design and size requirements resulting from a change from batch to continuous bioprocessing 3. Understand the difference in costs and automation level resulting from a change from batch to continuous bioprocessing

Categories

  1. Track
    Continuous Manufacturing Opportunities Keep Expanding

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